Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation.

@article{Kaga2006MiceWC,
  title={Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation.},
  author={Yoshimi Kaga and William J Shoemaker and Miki Furusho and Melissa B. Bryant and J. H. Rosenbluth and Steven E. Pfeiffer and L L L Oh and Matthew N Rasband and Corinna Lappe-Siefke and Kai Yu and David M Ornitz and K Nave and Rashmi Bansal},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 47},
  pages={12339-50}
}
Fibroblast growth factor receptors (Fgfr) comprise a widely expressed family of developmental regulators implicated in oligodendrocyte (OL) maturation of the CNS. Fgfr2 is expressed by OLs in myelinated fiber tracks. In vitro, Fgfr2 is highly upregulated during OL terminal differentiation, and its activation leads to enhanced growth of OL processes and the formation of myelin-like membranes. To investigate the in vivo function of Fgfr2 signaling by myelinating glial cells, we inactivated the… CONTINUE READING
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