Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy.

@article{Frank2014MiceWC,
  title={Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy.},
  author={Derk Frank and Ashraf Yusuf Rangrez and Reza Poyanmehr and Thalia S. Seeger and Christian Kuhn and Matthias Eden and Katharina Stiebeling and Alexander Bernt and Christine Grund and Werner Franke and Norbert Frey},
  journal={Journal of molecular and cellular cardiology},
  year={2014},
  volume={72},
  pages={196-207}
}
The intercalated disc (ID) is a major component of the cell-cell contact structures of cardiomyocytes and has been recognized as a hot spot for cardiomyopathy. We have previously identified Myozap as a novel cardiac-enriched ID protein, which interacts with several other ID proteins and is involved in RhoA/SRF signaling in vitro. To now study its potential role in vivo we generated a mouse model with cardiac overexpression of Myozap. Transgenic (Tg) mice developed cardiomyopathy with… CONTINUE READING

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