Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias.

@article{Morrow2011MiceWC,
  title={Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias.},
  author={John P. Morrow and Alexander N Katchman and Ni-Huiping Son and Chad M. Trent and Raffay S. Khan and Takayuki Shiomi and Haiyan Huang and Vaibhav Amin and Joshua M. Lader and Carolina V{\'a}squez and Gregory E. Morley and Jeanine M D'armiento and Shunichi Homma and Ira J Goldberg and Steven O. Marx},
  journal={Circulation},
  year={2011},
  volume={124 25},
  pages={2812-21}
}
BACKGROUND Diabetes mellitus and obesity, which confer an increased risk of sudden cardiac death, are associated with cardiomyocyte lipid accumulation and altered cardiac electric properties, manifested by prolongation of the QRS duration and QT interval. It is difficult to distinguish the contribution of cardiomyocyte lipid accumulation from the contribution of global metabolic defects to the increased incidence of sudden death and electric abnormalities. METHODS AND RESULTS In order to… CONTINUE READING
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Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2011

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