Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis.

@article{Sahrbacher1998MiceWA,
  title={Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis.},
  author={U C Sahrbacher and Franziska Lechner and H P Eugster and Karl Frei and Hans Lassmann and Adriano Fontana},
  journal={European journal of immunology},
  year={1998},
  volume={28 4},
  pages={1332-8}
}
Nitric oxide (NO) generated by the inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). In this study mice genetically deficient for iNOS are shown to be susceptible to EAE induced by immunization with myelin oligodendrocyte glycoprotein (MOG). In iNOS (-/-) mice the course of disease was earlier in onset and more aggressive compared to control animals. A disease-relevant compensatory up-regulation of neuronal (n)NOS… CONTINUE READING
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