Mice with an anterior cleft of the palate survive neonatal lethality.

@article{Gu2008MiceWA,
  title={Mice with an anterior cleft of the palate survive neonatal lethality.},
  author={Shuping Gu and Na Wei and Xueyan Yu and Yiping Jiang and Jian Fei and Yiping Chen},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2008},
  volume={237 5},
  pages={1509-16}
}
Many genes are known to function in a region-specific manner in the developing secondary palate. We have previously shown that Shox2-deficient embryos die at mid-gestation stage and develop an anterior clefting phenotype. Here, we show that mice carrying a conditional inactivation of Shox2 in the palatal mesenchyme survive the embryonic and neonatal lethality, but develop a wasting syndrome. Phenotypic analyses indicate a delayed closure of the secondary palate at the anterior end, leading to a… CONTINUE READING