Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.

Abstract

Hedgehog (Hh) signaling plays pivotal roles in tissue patterning and development in Drosophila melanogaster and vertebrates. The Patched1 (Ptc1) gene, encoding the Hh receptor, is mutated in nevoid basal cell carcinoma syndrome, a human genetic disorder associated with developmental abnormalities and increased incidences of basal cell carcinoma (BCC) and… (More)

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Cite this paper

@article{Nieuwenhuis2006MiceWA, title={Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.}, author={Erica Nieuwenhuis and Jun Motoyama and Paul C Barnfield and Yoshiaki Yoshikawa and Xiaoyun Zhang and Rong Mo and Michael A. Crackower and Chi-Chung Hui}, journal={Molecular and cellular biology}, year={2006}, volume={26 17}, pages={6609-22} }