Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy.

@article{Han2013MiceWA,
  title={Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy.},
  author={Sang Beom Han and Heng-Pei Ang and Rebekah W Y Poh and Shyam Sunder Chaurasia and Gary S L Peh and Jun Liu and Donald Tiang-Hwee Tan and Eranga Vithana and Jodhbir S. Mehta},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 9},
  pages={6179-89}
}
PURPOSE To establish an animal model of congenital hereditary endothelial dystrophy (CHED) using Slc4a11 knockout (KO) mice and evaluate the abnormalities in the cornea and kidney. METHODS The Slc4a11 KO mouse model was generated by gene deletion. Corneal abnormalities were evaluated using slit-lamp photography, anterior segment optical coherence tomography (AS-OCT), immunohistochemistry, RT-PCR, corneal endothelial cell staining, and electron microscopy. The temporal corneal changes were… CONTINUE READING
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