Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni.

@article{King1997MiceWA,
  title={Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni.},
  author={Christopher L King and Jia Xianli and Indu J Malhotra and Sucai Liu and Adel A. F. Mahmoud and Hans C. Oettgen},
  journal={Journal of immunology},
  year={1997},
  volume={158 1},
  pages={294-300}
}
Although IgE has been considered to play an essential role in host defense against parasitic helminth infections such as Schistosoma mansoni, in vivo evidence of a protective function of IgE in infected mice is lacking. In the present study, mice with a null mutation of the C epsilon gene, and thus incapable of making IgE (IgE deficient), were infected by S. mansoni cercariae percutaneously. In two independent experiments, IgE-deficient mice were significantly more susceptible to primary… CONTINUE READING