Mice with a selective impairment of IFN-gamma signaling in macrophage lineage cells demonstrate the critical role of IFN-gamma-activated macrophages for the control of protozoan parasitic infections in vivo.

@article{Lykens2010MiceWA,
  title={Mice with a selective impairment of IFN-gamma signaling in macrophage lineage cells demonstrate the critical role of IFN-gamma-activated macrophages for the control of protozoan parasitic infections in vivo.},
  author={Jennifer E. Lykens and Catherine E. Terrell and Erin E. Zoller and Senad Divanovic and Aur{\'e}lien Trompette and Christopher L. Karp and J{\'u}lio C. S. Aliberti and Matthew J. Flick and Michael B. Jordan},
  journal={Journal of immunology},
  year={2010},
  volume={184 2},
  pages={877-85}
}
IFN-gamma has long been recognized as a cytokine with potent and varied effects in the immune response. Although its effects on specific cell types have been well studied in vitro, its in vivo effects are less clearly understood because of its diverse actions on many different cell types. Although control of multiple protozoan parasites is thought to depend critically on the direct action of IFN-gamma on macrophages, this premise has never been directly proven in vivo. To more directly examine… CONTINUE READING
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