Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior.

@article{Ruan2016MiceWS,
  title={Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior.},
  author={C. S. Ruan and Chun-Rui Yang and Jia-yi Li and Hai-Yun Luo and Larisa Bobrovskaya and Xin-fu Zhou},
  journal={Experimental neurology},
  year={2016},
  volume={281},
  pages={99-108}
}
Exposure to stressful life events plays a central role in the development of mood disorders in vulnerable individuals. However, the mechanisms that link mood disorders to stress are poorly understood. Brain-derived neurotrophic factor (BDNF) has long been implicated in positive regulation of depression and anxiety, while its precursor (proBDNF) recently… CONTINUE READING