Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

@article{Zhou2016MiceWS,
  title={Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects},
  author={Yang Zhou and Tobias Kaiser and Patr{\'i}cia Monteiro and Xiangyu Zhang and Marie. S. Van der Goes and Dongqing Wang and Boaz Barak and Menglong Zeng and Chenchen Li and Congyi Lu and Michael Wells and Aldo Amaya and Shannon J Nguyen and Michael Lewis and Neville E. Sanjana and Yongdi Zhou and Mingjie Zhang and Feng Zhang and Zhanyan Fu and Guoping Feng},
  journal={Neuron},
  year={2016},
  volume={89},
  pages={147-162}
}
Genetic studies have revealed significant overlaps of risk genes among psychiatric disorders. However, it is not clear how different mutations of the same gene contribute to different disorders. We characterized two lines of mutant mice with Shank3 mutations linked to ASD and schizophrenia. We found both shared and distinct synaptic and behavioral phenotypes. Mice with the ASD-linked InsG3680 mutation manifest striatal synaptic transmission defects before weaning age and impaired juvenile… CONTINUE READING
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