Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide

@article{Kamijo1993MiceTL,
  title={Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide},
  author={Ryutaro Kamijo and J. -Y. Le and Deborah E. Shapiro and Edward A. Havell and Shuang Huang and Michel Aguet and Maarten C. Bosland and Jan Vil{\vc}ek},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={178},
  pages={1435 - 1440}
}
Mice with a targeted disruption of the interferon gamma receptor gene (IFN-gamma R0/0 mice) and control wild-type mice were inoculated with the Bacillus Calmette-Guérin (BCG) strain of Mycobacterium bovis. BCG infection was not lethal for wild-type mice whereas all IFN-gamma R0/0 mice died approximately 7-9 wk after inoculation. Histological examination at 2 and 6 wk after BCG inoculation showed that livers of IFN-gamma R0/0 mice had higher numbers of acid-fast bacteria than wild-type mice… CONTINUE READING

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References

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Showing 1-10 of 30 references

Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria

G. E. Gran, L. F. Fajardo, +3 authors P. Vassalli
Science (Wash. DC) • 1987
View 11 Excerpts
Highly Influenced

An endotoxin-induced serum factor that causes necrosis of tumors.

Proceedings of the National Academy of Sciences of the United States of America • 1975
View 11 Excerpts
Highly Influenced

Generation of nitric oxide and induction of MHC class II antigen in macrophages from mice lacking the IFN-'y receptor

Kamijo, IL, +4 authors J. V'deek
Proa Natl. Acad. Sci. USA • 1993
View 2 Excerpts

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