Mice selected for high versus low stress reactivity: a new animal model for affective disorders.

@article{Touma2008MiceSF,
  title={Mice selected for high versus low stress reactivity: a new animal model for affective disorders.},
  author={Chadi Touma and Mirjam Bunck and Lisa Glasl and Markus Nussbaumer and Rupert Palme and Hendrik Stein and Michael Wolferst{\"a}tter and Ramona Zeh and Marina Zimbelmann and Florian Holsboer and Rainer Landgraf},
  journal={Psychoneuroendocrinology},
  year={2008},
  volume={33 6},
  pages={839-62}
}
Affective disorders such as major depression are among the most prevalent and costly diseases of the central nervous system, but the underlying mechanisms are still poorly understood. In recent years, it has become evident that alterations of the stress hormone system, in particular dysfunctions (hyper- or hypo-activity) of the hypothalamic-pituitary-adrenal (HPA) axis, play a prominent role in the development of major depressive disorders. Therefore, we aimed to generate a new animal model… CONTINUE READING

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Effects of sex and time of day on metabolism and excretion of corticosterone in urine and feces of mice

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