Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.

@article{Phillips2010MiceOT,
  title={Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.},
  author={Darci Phillips and Michiel ten Hove and J{\"u}rgen E. Schneider and Colin O. Wu and Liam M Sebag-Montefiore and Angel Aponte and Craig A Lygate and Julie Wallis and Kieran Clarke and H. V. Watkins and Robert S Balaban and Stefan Neubauer},
  journal={Journal of molecular and cellular cardiology},
  year={2010},
  volume={48 4},
  pages={582-90}
}
The metabolic phenotype of the failing heart includes a decrease in phosphocreatine and total creatine concentration [Cr], potentially contributing to contractile dysfunction. Surprisingly, in 32- week-old mice over-expressing the myocardial creatine transporter (CrT-OE), we previously demonstrated that elevated [Cr] correlates with left ventricular (LV) hypertrophy and failure. The aim of this study was to determine the temporal relationship between elevated [Cr] and the onset of cardiac… CONTINUE READING

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