Mice over-expressing the 5-HT(1A) receptor in cortex and dentate gyrus display exaggerated locomotor and hypothermic response to 8-OH-DPAT.

@article{Bert2006MiceOT,
  title={Mice over-expressing the 5-HT(1A) receptor in cortex and dentate gyrus display exaggerated locomotor and hypothermic response to 8-OH-DPAT.},
  author={Bettina Bert and Heidrun Fink and Heide H{\"o}rtnagl and R{\"u}diger W Veh and Ben Davies and Franz Theuring and Heike Kusserow},
  journal={Behavioural brain research},
  year={2006},
  volume={167 2},
  pages={328-41}
}
The serotonin 1A (5-HT(1A)) receptor is one of the best described receptor subtypes of the serotonergic system. Due to the complex distribution pattern, the pre- and postsynaptic localisation, the impact on various monoamines, as well as the influence on a wide range of physiological functions, the contribution of 5-HT(1A) receptors to behavioural outcomes is difficult to define. In this study, we present a new transgenic mouse model with a prominent over-expression of the 5-HT(1A) receptor in… CONTINUE READING
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