Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation.

@article{Farrelly1999MiceMF,
  title={Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation.},
  author={Dennis Farrelly and Kirsty S Brown and Aaron Tieman and Junhong Ren and Sergio A Lira and Dm. Hagan and Richard A. Gregg and Kasim A. Mookhtiar and Narayanan Hariharan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 25},
  pages={
          14511-6
        }
}
The importance of glucokinase (GK; EC 2.7.1.12) in glucose homeostasis has been demonstrated by the association of GK mutations with diabetes mellitus in humans and by alterations in glucose metabolism in transgenic and gene knockout mice. Liver GK activity in humans and rodents is allosterically inhibited by GK regulatory protein (GKRP). To further understand the role of GKRP in GK regulation, the mouse GKRP gene was inactivated. With the knockout of the GKRP gene, there was a parallel loss of… CONTINUE READING
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