Mice lacking vimentin develop and reproduce without an obvious phenotype.

@article{ColucciGuyon1994MiceLV,
  title={Mice lacking vimentin develop and reproduce without an obvious phenotype.},
  author={Emma Colucci-Guyon and M M Portier and Irene Dunia and Denise Paulin and S. Pournin and Charles Babinet},
  journal={Cell},
  year={1994},
  volume={79 4},
  pages={679-94}
}
To address the biological role of vimentin in the context of the living organism, we have introduced a null mutation of the vimentin gene into the germ line of mice. Surprisingly, animals homozygous for this mutation developed and reproduced without an obvious phenotype. Immunoblotting, immunofluorescence, and immunogold labeling analysis confirmed the absence of vimentin and of the corresponding filament network. Furthermore, no compensatory expression of another intermediate filament could be… CONTINUE READING
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