Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals.

@article{Hui2004MiceLT,
  title={Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals.},
  author={To Yuen Hui and Sonal S. Sheth and J. Matthew Diffley and Douglas W Potter and Aldons J. Lusis and Alan D Attie and Roger A. Davis},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 23},
  pages={24387-93}
}
Thioredoxin-interacting protein (Txnip) is a ubiquitous protein that binds with high affinity to thioredoxin and inhibits its ability to reduce sulfhydryl groups via NADPH oxidation. HcB-19 mice contain a nonsense mutation in Txnip that eliminates its expression. Unlike normal animals, HcB-19 mice have approximately 3-fold increase in insulin levels when fasted. The C-peptide/insulin ratio is normal, suggesting that the hyperinsulinemia is due to increased insulin secretion. Fasted HcB-19 mice… CONTINUE READING