Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia.

@article{Bellomo2000MiceLT,
  title={Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia.},
  author={Daniela Bellomo and John P Headrick and G U Silins and Carl Paterson and Paul Thomas and Michael G. Gartside and Arne W Mould and M M Cahill and Ian D Tonks and Sean M. Grimmond and Simon Townson and Christine Wells and Melissa Little and Margaret C. Cummings and N. K. Hayward and Graham F. Kay},
  journal={Circulation research},
  year={2000},
  volume={86 2},
  pages={E29-35}
}
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. To further study the in vivo function of VEGF-B, we have generated Vegfb knockout mice (Vegfb(-/-)). Unlike Vegfa knockout mice, which die during embryogenesis, Vegfb(-/-) mice are healthy and fertile. Despite appearing overtly normal, Vegfb(-/-) hearts are reduced in size and display vascular dysfunction… CONTINUE READING

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