Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization

@article{Zhao2016MiceLT,
  title={Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization},
  author={Chengzhu Zhao and Atsuhiko Ichimura and Nianchao Qian and Tsunaki Iida and Daiju Yamazaki and Naruto Noma and Masataka Asagiri and Koji Yamamoto and Shinji Komazaki and Chikara Sato and Fumiyo Aoyama and Akira Sawaguchi and Sho Kakizawa and Miyuki Nishi and Hiroshi Takeshima},
  journal={Science Signaling},
  year={2016},
  volume={9},
  pages={ra49-ra49}
}
The trimeric intracellular cation (TRIC) channels TRIC-A and TRIC-B localize predominantly to the endoplasmic reticulum (ER) and likely support Ca2+ release from intracellular stores by mediating cationic flux to maintain electrical neutrality. Deletion and point mutations in TRIC-B occur in families with autosomal recessive osteogenesis imperfecta. Tric-b knockout mice develop neonatal respiratory failure and exhibit poor bone ossification. We investigated the cellular defect causing the bone… CONTINUE READING
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Roles of the calciotropic and phosphotropic hormones

  • C. S. Kovacs, Bone development, mineral homeostasis in the fetus, neonate
  • Physiol. Rev. 94, 1143–1218
  • 2014
1 Excerpt

Vrahnas, Regulation of cortical and trabecular bone mass by communication between osteoblasts, osteocytes and osteoclasts

  • C.N.A. Sims
  • Arch. Biochem. Biophys. 561,
  • 2014
2 Excerpts

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