Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes.

@article{Wurbel2001MiceLT,
  title={Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes.},
  author={M A Wurbel and Marie Malissen and Delphine Guy-Grand and Eric Meffre and Michel C. Nussenzweig and Mireille Richelme and Alice Carrier and Bernard Malissen},
  journal={Blood},
  year={2001},
  volume={98 9},
  pages={
          2626-32
        }
}
CC chemokine receptor (CCR) 9, the receptor for the CC-chemokine CCL25/thymus-expressed chemokine (TECK), is mainly expressed by thymocytes and by intraepithelial (IEL) and lamina propria lymphocytes of the small intestine. To study the biologic role of CCR9, a mouse strain was generated in which the CCR9 gene was deleted. In spite of the high level of CCR9 found in double- and single-positive thymocytes and of the expression of its corresponding ligand on thymic stromal cells, CCR9 deletion… CONTINUE READING

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Human thymus

  • S Vandenabeele, H Hochrein, N Mavaddat, K Winkel, K. Shortman
  • For personal use only. on August
  • 2001

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