Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia.

@article{Alb2003MiceLP,
  title={Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia.},
  author={James G. Alb and Jorge Daniel Cortese and Scott E. Phillips and Roger L Albin and Tim R Nagy and Bruce A Hamilton and Vytas A Bankaitis},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 35},
  pages={33501-18}
}
Phosphatidylinositol transfer proteins (PITPs) regulate the interface between lipid metabolism and cellular functions. We now report that ablation of PITP alpha function leads to aponecrotic spinocerebellar disease, hypoglycemia, and intestinal and hepatic steatosis in mice. The data indicate that hypoglycemia is in part associated with reduced proglucagon… CONTINUE READING