Mice lacking histidine decarboxylase exhibit abnormal mast cells.

@article{Ohtsu2001MiceLH,
  title={Mice lacking histidine decarboxylase exhibit abnormal mast cells.},
  author={Hiroshi Ohtsu and Shigeki Tanaka and Tadashi Terui and Yuichi Hori and Yoko Makabe-Kobayashi and Gunnar Pejler and Elena Tchougounova and Lars Hellman and Marina Gertsenstein and Noriyasu Hirasawa and Einosuke Sakurai and Edit Ir{\'e}n Buz{\'a}s and Peter Kovacs and Gy{\"o}rgy Csaba and A Kittel and Masato Okada and Masayuki Hara and Leong Mar and Keiko Numayama-Tsuruta and Satsuki Ishigaki-Suzuki and Kazuo Ohuchi and Atsushi Ichikawa and Andr{\'a}s Falus and T Watanabe and Andr{\'a}s Nagy},
  journal={FEBS letters},
  year={2001},
  volume={502 1-2},
  pages={
          53-6
        }
}
  • Hiroshi Ohtsu, Shigeki Tanaka, +22 authors András Nagy
  • Published in FEBS letters 2001
  • Biology, Medicine
  • Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine-synthesizing activity from histidine. These HDC-deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 167 CITATIONS, ESTIMATED 45% COVERAGE

    Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions.

    VIEW 4 EXCERPTS
    CITES BACKGROUND & METHODS
    HIGHLY INFLUENCED

    Analysis of histamine receptor knockout mice in models of inflammation.

    VIEW 5 EXCERPTS
    CITES BACKGROUND & METHODS
    HIGHLY INFLUENCED

    HISTAMINE IN ALLERGIC DISEASES : AN OLD MOLECULE IN NEW CONCEPTS

    VIEW 7 EXCERPTS
    CITES METHODS & BACKGROUND
    HIGHLY INFLUENCED

    Biological implications of preformed mast cell mediators

    VIEW 6 EXCERPTS
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2002
    2020

    CITATION STATISTICS

    • 9 Highly Influenced Citations

    • Averaged 7 Citations per year from 2017 through 2019