Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block

@article{Simon1998MiceLC,
  title={Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block},
  author={Alexander M. Simon and Daniel A. Goodenough and David L. Paul},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={295-298}
}
Activation of cardiac muscle is mediated by the His-Purkinje system, a discrete pathway containing fast-conducting cells (Purkinje fibers) which coordinate the spread of excitation from the atrioventricular node (AV node) to ventricular myocardium [1]. Although pathologies of this specialized conduction system are common in humans, especially among the elderly [2], their molecular bases have not been defined. Gap junctions are present at appositions between Purkinje fibers and could provide a… CONTINUE READING