Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.

@article{Li2006MiceLC,
  title={Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.},
  author={Chao Yang Li and K J Leni Jepsen and Robert J. Majeska and Jian Zhang and Rujing Ni and Bruce D Gelb and Mitchell B. Schaffler},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2006},
  volume={21 6},
  pages={865-75}
}
UNLABELLED Bone microstructural and biomechanical properties were analyzed in mice genetically lacking cathepsin K (CatK). CatK deficiency (CatK(-/-)) produced mild osteopetrosis, elevated numbers of osteoclasts, regions of disorganized bone microstructure, and increased bone fragility, showing how chronic alteration of enzyme activity during skeletal development dramatically affects bone organization and function. INTRODUCTION Mouse models of CatK deficiency recapitulate the osteopetrosis of… CONTINUE READING