Mice lacking brain-derived neurotrophic factor develop with sensory deficits

@article{Ernfors1994MiceLB,
  title={Mice lacking brain-derived neurotrophic factor develop with sensory deficits},
  author={Patrik Ernfors and Kwanghaeng Lee and Rudolf Jaenisch},
  journal={Nature},
  year={1994},
  volume={368},
  pages={147-150}
}
DURING vertebrate development, neuronal survival depends on target-derived neurotrophic factors1,2. Brain-derived neurotrophic factor3 (BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons in vitro4–6, and of central motor neurons as well as dopaminergic and cholinergic neurons of the basal forebrain during development7–9. It also prevents the death of motor neurons and midbrain dopaminergic neurons induced by lesions8,10–12. Here we show… CONTINUE READING
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