Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

@article{Sur2012MiceLA,
  title={Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.},
  author={Inderpreet Sur and Outi K Hallikas and Anna V{\"a}h{\"a}rautio and Jian Yan and Mikko M. Turunen and Martin Enge and Minna Taipale and Auli Karhu and Lauri A. Aaltonen and Jussi Taipale},
  journal={Science},
  year={2012},
  volume={338 6112},
  pages={1360-3}
}
Multiple cancer-associated single-nucleotide polymorphisms (SNPs) have been mapped to conserved sequences within a 500-kilobase region upstream of the MYC oncogene on human chromosome 8q24. These SNPs may affect cancer development through altered regulation of MYC expression, but this hypothesis has been difficult to confirm. We generated mice deficient in Myc-335, a putative MYC regulatory element that contains rs6983267, a SNP accounting for more human cancer-related morbidity than any other… CONTINUE READING
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