Mice lacking a CDK inhibitor, p57Kip2, exhibit skeletal abnormalities and growth retardation.

@article{Takahashi2000MiceLA,
  title={Mice lacking a CDK inhibitor, p57Kip2, exhibit skeletal abnormalities and growth retardation.},
  author={Katsuhiko Takahashi and Kazuhisa Nakayama},
  journal={Journal of biochemistry},
  year={2000},
  volume={127 1},
  pages={73-83}
}
p57Kip2, one of the cyclin-dependent kinase (CDK) inhibitors, has been suggested to be a tumor suppressor candidate. To elucidate its biological roles in mouse development and tumorigenesis, we created p57Kip2-deficient mice. The p57Kip2-deficient mice exhibited a cleft palate and defective bone formation resulting in severe dyspnea. Most of the p57Kip2-deficient mice died within 24 h after birth, while about 10% of them survived beyond the weaning period. All of the surviving mice showed… CONTINUE READING

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