Mice lacking NKCC1 have normal olfactory sensitivity.

  title={Mice lacking NKCC1 have normal olfactory sensitivity.},
  author={David E Smith and Sokunthirith Thach and Erika L Marshall and Mary-Grace Mendoza and Steven J. Kleene},
  journal={Physiology & behavior},
  volume={93 1-2},
When olfactory receptor neurons respond to odors, a depolarizing Cl(-) efflux is a substantial part of the response. This requires that the resting neuron accumulate Cl(-) against an electrochemical gradient. In isolated olfactory receptor neurons, the Na(+)+K(+)+2Cl(-) cotransporter NKCC1 is essential for Cl(-) accumulation. However, in intact epithelium, a robust electrical olfactory response persists in mice lacking NKCC1. To determine whether NKCC1 is required for normal olfactory… CONTINUE READING


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