Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.

@article{Wu2006MiceLM,
  title={Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.},
  author={Jing Wu and Rachel J Roth and Ethan J. Anderson and E G Hong and M. Lee and Cheol Soo Choi and P. Darrell Neufer and Gerald I Shulman and Jason Kim and Anton M Bennett},
  journal={Cell metabolism},
  year={2006},
  volume={4 1},
  pages={61-73}
}
The mitogen-activated protein kinases (MAPK) play critical roles in the pathogenesis of diabetes and obesity. The MAPKs are inactivated by MAPK phosphatases (MKPs) either in the cytosol or nucleus. Here we show that mice lacking the nuclear-localized MKP, MKP-1 (mkp-1(-/-)), have enhanced Erk, p38 MAPK and c-Jun NH(2)-terminal kinase (JNK) activities in… CONTINUE READING