Mice lacking CD200R1 show absence of suppression of lipopolysaccharide-induced tumor necrosis factor-alpha and mixed leukocyte culture responses by CD200.

@article{Boudakov2007MiceLC,
  title={Mice lacking CD200R1 show absence of suppression of lipopolysaccharide-induced tumor necrosis factor-alpha and mixed leukocyte culture responses by CD200.},
  author={Ivo Y. Boudakov and Jian Liu and Na Fan and Pelin Gulay and Karrie K Wong and Reginald M Gorczynski},
  journal={Transplantation},
  year={2007},
  volume={84 2},
  pages={251-7}
}
BACKGROUND CD200:CD200R interactions deliver immunoregulatory signals. A family of CD200Rs (CD200R1-5) has been described, and engagement of CD200R1 by its ligand CD200 suppresses LPS-induced macrophage cytokine production, decreases alloimmune responses in vivo and in vitro, and suppresses collagen-induced arthritis. METHODS We generated C57BL/6 mice lacking the genomic exons encoding the extracellular domains of the CD200R1 molecule using transformation of ES cells and explored cell… CONTINUE READING