Mice immunized with a subviral particle containing the Japanese encephalitis virus prM/M and E proteins are protected from lethal JEV infection.

@article{Konishi1992MiceIW,
  title={Mice immunized with a subviral particle containing the Japanese encephalitis virus prM/M and E proteins are protected from lethal JEV infection.},
  author={Eiji Konishi and Seth Pincus and Enzo Paoletti and Robert E. Shope and T. Burrage and Peter W. Mason},
  journal={Virology},
  year={1992},
  volume={188 2},
  pages={714-20}
}
Extracellular subviral particles produced by HeLa cells infected with a recombinant vaccinia virus encoding the prM and E genes of Japanese encephalitis virus (JEV) were purified and characterized. These particles contained the JEV prM/M and E proteins embedded in a lipid bilayer, and RNA was not detected in particles using the polymerase chain reaction and primers recognizing a part of the JEV E gene. The particles were uniformly spherical with a 20-nm diameter and had 5-nm projections on… CONTINUE READING

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