Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm.

@article{Zimmer2012MiceHF,
  title={Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm.},
  author={Stephanie N Zimmer and M. Lemieux and Bijal P Karia and C. Day and T. Zhou and Qing Zhou and A. Kung and U. Suresh and Y. Chen and M. Kinney and Alexander J. R. Bishop and V. I. Rebel},
  journal={Experimental hematology},
  year={2012},
  volume={40 4},
  pages={
          295-306.e5
        }
}
Myelodysplastic syndrome is a complex family of preleukemic diseases in which hematopoietic stem cell defects lead to abnormal differentiation in one or more blood lineages. Disease progression is associated with increasing genomic instability and a large proportion of patients go on to develop acute myeloid leukemia. Primarily a disease of the elderly, it can also develop after chemotherapy. We have previously reported that CREB binding protein (Crebbp) heterozygous mice have an increased… Expand
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