Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm.

@article{Zimmer2012MiceHF,
  title={Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm.},
  author={Stephanie N Zimmer and Madeleine E Lemieux and Bijal P Karia and Claudia Day and Ting Zhou and Qing Zhou and Andrew L Kung and Uthra Suresh and Yidong Chen and Marsha C. Kinney and Alexander James Roy Bishop and Vivienne I. Rebel},
  journal={Experimental hematology},
  year={2012},
  volume={40 4},
  pages={
          295-306.e5
        }
}
Myelodysplastic syndrome is a complex family of preleukemic diseases in which hematopoietic stem cell defects lead to abnormal differentiation in one or more blood lineages. Disease progression is associated with increasing genomic instability and a large proportion of patients go on to develop acute myeloid leukemia. Primarily a disease of the elderly, it can also develop after chemotherapy. We have previously reported that CREB binding protein (Crebbp) heterozygous mice have an increased… CONTINUE READING

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