Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes.

@article{Dhar2004MiceHF,
  title={Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes.},
  author={Madhu Dhar and Carla S. Sommardahl and Tanisa Kirkland and Sarah Nelson and Robert Donnell and Dabney K. Johnson and Lawrence W. Castellani},
  journal={The Journal of nutrition},
  year={2004},
  volume={134 4},
  pages={
          799-805
        }
}
Atp10c is a novel type IV P-type ATPase and is a putative phospholipid transporter. The purpose of this study was to assess the overall effect of the heterozygous deletion of Atp10c on obesity-related phenotypes and metabolic abnormalities in mice fed a high-fat diet. Heterozygous mice with maternal inheritance of Atp10c were compared with heterozygous mice with paternal inheritance of Atp10c and wild-type controls. Body weight, adiposity index, and plasma insulin, leptin and triglyceride… CONTINUE READING

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