Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons

  title={Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons},
  author={J. Criado and M. S{\'a}nchez-Alavez and B. Conti and J. Giacchino and M. Oldstone},
  journal={Neurobiology of Disease},
  • J. Criado, M. Sánchez-Alavez, +2 authors M. Oldstone
  • Published 2005
  • Biology, Medicine
  • Neurobiology of Disease
  • Prion protein (PrP(C)) is a constituent of most normal mammalian cells and plays an essential role in the pathogenesis of transmissible spongiform encephalopathies (TSE). However, the normal cellular function of PrP(C) remains unclear. Here, we document that mice with a selective deletion of PrP(C) exhibited deficits in hippocampal-dependent spatial learning, but non-spatial learning remained intact. mPrP-/- mice also showed reduction in paired-pulse facilitation and long-term potentiation in… CONTINUE READING
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