Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.

@article{Gthe1999MiceDO,
  title={Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.},
  author={Susanne G{\"o}the and Zhigang Wang and Lily Ng and Jeanne M. Meis Kindblom and Ana Cristina Barros and C Ohlsson and Bj{\"o}rn Vennstr{\"o}m and Dana Forrest},
  journal={Genes & development},
  year={1999},
  volume={13 10},
  pages={1329-41}
}
Thyroid hormone (T3) has widespread functions in development and homeostasis, although the receptor pathways by which this diversity arises are unclear. Deletion of the T3 receptors TRalpha1 or TRbeta individually reveals only a small proportion of the phenotypes that arise in hypothyroidism, implying that additional pathways must exist. Here, we demonstrate that mice lacking both TRalpha1 and TRbeta (TRalpha1(-/-)beta-/-) display a novel array of phenotypes not found in single receptor… CONTINUE READING
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Effect of thyroid hormone and growth hormone on recovery from hypothyroidism of epiphyseal growth plate cartilage and its adjacent bone

  • C. Longcope
  • Endocrinology
  • 1989

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