Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors.

@article{Ide2000MiceDI,
  title={Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors.},
  author={Fumio Ide and Naoko Iida and Yoko Nakatsuru and Hiroko Oda and Kiyoji Tanaka and Takatoshi Ishikawa},
  journal={Carcinogenesis},
  year={2000},
  volume={21 6},
  pages={1263-5}
}
This study is focused on chemical induction of lung tumors in xeroderma pigmentosum group A gene (XPA)-deficient mice to clarify the role of nucleotide excision repair (NER) in internal organs. Six-week-old female XPA-/-, XPA(+/-) and XPA(+/+) mice were instilled intratracheally with benzo[a] pyrene (B[a]P). A total of 68 surviving XPA mice treated with B[a]P were examined at month 16. The pulmonary adenoma incidence in XPA(-/-) mice was significantly higher than that in XPA(+/+) mice (71… CONTINUE READING
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