Mice deficient in plasminogen activator inhibitor-1 have improved skeletal muscle regeneration.

@article{Koh2005MiceDI,
  title={Mice deficient in plasminogen activator inhibitor-1 have improved skeletal muscle regeneration.},
  author={Timothy J Koh and Scott C. Bryer and Augustina M Pucci and Thomas H. Sisson},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={289 1},
  pages={C217-23}
}
Skeletal muscle possesses a remarkable capacity for regeneration. Although the regulation of this process at the molecular level remains largely undefined, the plasminogen system appears to play a critical role. Specifically, mice deficient in either urokinase-type plasminogen activator (uPA-/- mice) or plasminogen demonstrate markedly impaired muscle regeneration after injury. In the present study, we tested the hypothesis that loss of the primary inhibitor of uPA, plasminogen activator… CONTINUE READING

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