Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility.

Abstract

The double-stranded RNA (dsRNA)-induced interferon response is a defense mechanism against viral infection. Upon interferon activation by dsRNA, 2',5'-oligoadenylate synthetase 1 (OAS1A) is induced; it binds dsRNA and converts ATP into 2',5'-linked oligomers of adenosine (called 2-5A), which activate RNase L that in turn degrades viral and cellular RNAs. In… (More)

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Cite this paper

@article{Yan2005MiceDI, title={Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility.}, author={Wei Yan and Lang Ma and Paula Stein and Stephanie A. Pangas and Kathleen H. Burns and Yuchen Bai and Richard M Schultz and Martin M. Matzuk}, journal={Molecular and cellular biology}, year={2005}, volume={25 11}, pages={4615-24} }