Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates.

@article{Ghandour2004MiceDI,
  title={Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates.},
  author={Haifa Ghandour and Zhoutao Chen and Jacob S Selhub and Rima Rozen},
  journal={The Journal of nutrition},
  year={2004},
  volume={134 11},
  pages={2975-8}
}
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), which is used for homocysteine remethylation to methionine, the precursor of S-adenosylmethionine (SAM). Impairment of MTHFR will increase homocysteine levels and compromise SAM-dependent methylation reactions. Mild MTHFR deficiency is common in many populations due to a polymorphism at bp 677. To assess how impaired MTHFR activity affects folate metabolism in various tissues in vivo… CONTINUE READING
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