Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system.

@article{Saftig1997MiceDI,
  title={Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system.},
  author={Paul Saftig and Dieter Hartmann and Renate L{\"u}llmann-Rauch and Jessica Wolff and Matthias Evers and Anja Koester and Michal Hetman and Kurt von Figura and Christoph Peters},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 30},
  pages={18628-35}
}
Lysosomal acid phosphatase (LAP) is a tartrate-sensitive enzyme with ubiquitous expression. Neither the physiological substrates nor the functional significance is known. Mice with a deficiency of LAP generated by targeted disruption of the LAP gene are fertile and develop normally. Microscopic examination of various peripheral organs revealed progredient lysosomal storage in podocytes and tubular epithelial cells of the kidney, with regionally different ultrastructural appearance of the stored… CONTINUE READING

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