Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier

@article{Sevilla2007MiceDI,
  title={Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier},
  author={Lisa M. Sevilla and Rachida Nachat and Karen Renee Groot and John F. Klement and Jouni Uitto and Philippe Djian and Arto M{\"a}{\"a}tt{\"a} and Fiona M Watt},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={179},
  pages={1599 - 1612}
}
The cornified envelope is assembled from transglutaminase cross-linked proteins and lipids in the outermost epidermal layers and is essential for skin barrier function. Involucrin, envoplakin, and periplakin form the protein scaffold on which the envelope assembles. To examine their combined function, we generated mice deficient in all three genes. The triple knockouts have delayed embryonic barrier formation and postnatal hyperkeratosis (abnormal accumulation of cornified cells) resulting from… CONTINUE READING

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