Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality.

@article{Habuchi2007MiceDI,
  title={Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality.},
  author={Hiroko Habuchi and Naoko Nagai and Noriko Sugaya and Fukiko Atsumi and Richard L. Stevens and Koji Kimata},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 21},
  pages={15578-88}
}
Heparan sulfate (HS) plays critical roles in a variety of developmental, physiological, and pathogenic processes due to its ability to interact in a structure-dependent manner with numerous growth factors that participate in cellular signaling. The divergent structures of HS glycosaminoglycans are the result of the coordinate actions of several N- and O-sulfotransferases, C5-epimerase, and 6-O-endosulfatases. We have shown that 6-O-sulfation of the glucosamine residues in HS are catalyzed by… CONTINUE READING