Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection.

@article{Endo2012MiceDI,
  title={Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection.},
  author={Yuichi Endo and Minoru Takahashi and Daisuke D Iwaki and Yumi Ishida and Naomi Nakazawa and Toshihisa Kodama and Tomohiro Matsuzaka and Kazuko Kanno and Yu Liu and Kohsuke Tsuchiya and I. K. Kawamura and Masahito Ikawa and Satoshi Waguri and Ikuo Wada and Misao Matsushita and Wilhelm J Schwaeble and Teizo Fujita},
  journal={Journal of immunology},
  year={2012},
  volume={189 12},
  pages={5860-6}
}
Mannose-binding lectin (MBL) and ficolin are complexed with MBL-associated serine proteases, key enzymes of complement activation via the lectin pathway, and act as soluble pattern recognition molecules in the innate immune system. Although numerous reports have revealed the importance of MBL in infectious diseases and autoimmune disorders, the role of ficolin is still unclear. To define the specific role of ficolin in vivo, we generated model mice deficient in ficolins. The ficolin A (FcnA… CONTINUE READING
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