Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire.

@article{Fleming2002MiceDI,
  title={Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire.},
  author={Sherry Diane Fleming and T Shea-Donohue and Joel M Guthridge and Liudmila Kulik and Thomas J Waldschmidt and Matthew G. Gipson and George C Tsokos and Vernon Michael Holers},
  journal={Journal of immunology},
  year={2002},
  volume={169 4},
  pages={
          2126-33
        }
}
Intestinal ischemia-reperfusion (IR) injury is initiated when natural Abs recognize neoantigens that are revealed on ischemic cells. Cr2(-/-) mice, deficient in complement receptors (CR)1 and CR2, demonstrate defects in T-dependent B-2 B cell responses to foreign Ags and have also been suggested to manifest abnormalities of the B-1 subset of B lymphocytes. To determine whether these CRs might play a role in the generation of the natural Abs that initiate intestinal IR injury, we performed… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

The role of complement in B cell activation and tolerance

M. C. Carroll
  • Adv. Immunol
  • 2000
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1996
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

B cell development pathways

J. F. Kearney
  • Annu . Rev . Immunol .
  • 2001

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