Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases.

@article{Anderson2006MiceDI,
  title={Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases.},
  author={Karen Anderson and Michael Fitzgerald and Michelle Dupont and Tao Wang and Nancy Paz and Marion Dorsch and Aileen M. Healy and Yajun Xu and Tim Ocain and Lisa Schopf and Bruce B. Jaffee and Dominic Picarella},
  journal={Autoimmunity},
  year={2006},
  volume={39 6},
  pages={469-78}
}
In the present study we have characterized T cell-driven immune function in mice that are genetically deficient in PKC theta. In response to simple immunologic stimulation invoked by in vivo T cell receptor (TCR) cross-linking, these mice showed significantly depressed plasma cytokine levels for IL-2, IL-4, IFNgamma, and TNFalpha compared to wild-type (WT) mice. In parallel, spleen mRNA levels for these cytokines were reduced, and NF-kappaB activation was also reduced in PKC theta knockouts (KO… CONTINUE READING