# Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

@article{Li1995MiceDI,
title={Mice deficient in IL-1$\beta$-converting enzyme are defective in production of mature IL-1$\beta$ and resistant to endotoxic shock},
author={Ping Li and Hamish Allen and Subhashish Banerjee and S Franklin and Linda Herzog and Cynthia G. Johnston and Jack McDowell and Michael Paskind and Laura Rodman and Jochen G. Salfeld and Elizabeth Towne and Daniel Edward Tracey and Scott D. Wardwell and Feng Wei and Winnie W. Wong and Robert I. Kamen and Tara Seshadri},
journal={Cell},
year={1995},
volume={80},
pages={401-411}
}
• Published 10 February 1995
• Biology
• Cell
1,357 Citations

## Figures and Tables from this paper

• Biology
• 1997
To address the biological functions of ICE, ICE‐deficient mice were generated through gene targeting technology and were resistant to LPS‐induced endotoxic shock and had impaired IL‐1α production on LPS stimulation in vitro and in vivo.
• Biology
• 1998
The crystal structure of ICE reveals that the active enzyme is composed of two 20-k Da and two 10-kDa subunits to form a tetramer (7,8), and this structure is similar to that of a Tournaisian tetramer.
• Biology, Medicine
American journal of physiology. Regulatory, integrative and comparative physiology
• 1998
It is demonstrated that intracerebroventricular injections of lipopolysaccharide (LPS) produced a greater reduction in both food intake and food-motivated behavior in wild-type mice compared with ICE-deficient (ICE -/-) mice.
• Biology
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
• 1999
Results show that ICE activity contributes to the progression of neonatal HI brain injury in this model, and whether these deleterious effects are mediated by proinflammatory actions of IL-lβ and/or by pro-apoptotic mechanisms is an important question for future studies.
• Biology, Medicine
Infection and Immunity
• 2000
It is concluded that, while caspase 1 is not indispensable for release of mature IL-1β in candidiasis, the casp enzyme 1-dependent production of IL-18 may represent an important and novel pathway for the expression of sustained Th1 reactivity to the fungus.
• Biology, Chemistry
The Journal of experimental medicine
• 1998
IL-1β but not IL-1α is crucial in febrile and neuro-immuno-endocrine responses, and that this is because IL- 1α expression in the brain is dependent on IL-2β, as well as in peritoneal macrophages stimulated with lipopolysaccharide in vitro.
• Biology
The Journal of experimental medicine
• 1996
It is demonstrated that pro-IL-1 beta is a substrate of ICE relevant to cell death, and depending on the temporal cellular commitment to apoptosis, mature IL-1beta may function as a positive or negative mediator of cell death.
• Biology, Medicine
• 1998
The results show that IL-18 is an IL-12–independent regulator of IFNγ production and of cell proliferation induced by microbial stimuli, however, ICE-dependent processing of IL- 18 is not needed for response to mitogens or antigens.
• Biology
• 1997
Recent data indicate that ICE is a member of an increasingly recognized family of cysteine proteases, in which IL-1b˜ acts as an autocrine growth factor, or induce apoptosis.
• Biology, Medicine
The Journal of clinical investigation
• 2001
We sought to determine whether mice deficient in the proinflammatory caspase-1, which cleaves precursors of IL-1 beta and IL-18, were protected against ischemic acute renal failure (ARF).

## References

SHOWING 1-10 OF 55 REFERENCES

• Biology, Chemistry
Proceedings of the National Academy of Sciences of the United States of America
• 1993
The striking similarities of the human and murine enzymes will make it possible to assess the therapeutic potential of hICE inhibitors in murine models of disease.
• Biology, Medicine
Science
• 1991
Some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo, but the serum levels of IgG1 and IgE are strongly reduced.
The recent cloning of a naturally occurring IL-1 receptor antagonist (IL-1ra) has opened new experimental and clinical approaches and reduced the severity of diseases such as hemodynamic shock, lethal sepsis, inflammatory bowel disease, experimental arthritis, and the spontaneous proliferation of human leukemic cells.
• Biology
Nature
• 1992
Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis.
• Biology, Medicine
Nature
• 1991
It is found that mice homozygous for the IL-2 gene mutation are normal with regard to thymocyte and peripheral T-cell subset composition, but that a dysregulation of the immune system is manifested by reduced polyclonal in vitro T- cell responses and by dramatic changes in the isotype levels of serum immunoglobulins.
• Biology
Proceedings of the National Academy of Sciences of the United States of America
• 1991
The findings suggest that cell injury is an important physiologic stimulus for release of IL-1, and the nature of the injury profoundly affects the forms ofIL-1 that are released.
• Biology
Journal of immunology
• 1994
The inability to identify active ICE in stimulated monocytic cells was probably a reflection of the very low levels of active ICE present.
• Biology
Proceedings of the National Academy of Sciences of the United States of America
• 1989
It is concluded that a protease activity found only in monocytes will specifically process IL-1 beta to an active form.
• Biology, Medicine
The Journal of experimental medicine
• 1991
These experiments provide direct evidence that the lethal effects of LPS may be mediated through the action of IL-1 and that theIL-1ra can provide a new treatment strategy for disease processes mediated via this cytokine.