Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation

@article{Li2000MiceDI,
  title={Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation},
  author={Baojie Li and Sharon Boast and Kenia de los Santos and Ira Schieren and Marisol E Quiroz and Steven L Teitelbaum and Mehrdad M Tondravi and Stephen P Goff},
  journal={Nature Genetics},
  year={2000},
  volume={24},
  pages={304-308}
}
The c-Abl protein is a non-receptor tyrosine kinase involved in many aspects of mammalian development. c-Abl kinase is widely expressed, but high levels are found in hyaline cartilage in the adult, bone tissue in newborn mice, and osteoblasts and associated neovasculature at sites of endochondrial ossification in the fetus. Mice homozygous for mutations in the gene encoding c-Abl (Abl) display increased perinatal mortality, reduced fertility, foreshortened crania and defects in the maturation… CONTINUE READING