Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control.

@article{Choi2002MiceDF,
  title={Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control.},
  author={Jene Choi and Bonnie W Nannenga and Oleg N. Demidov and Dmitry V Bulavin and Austin John Cooney and Cory E Brayton and Yongxin Zhang and Innocent Nnadi Mbawuike and Allan Bradley and Ettore Appella and Lawrence A. Donehower},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 4},
  pages={1094-105}
}
The Wip1 gene is a serine/threonine phosphatase that is induced in a p53-dependent manner by DNA-damaging agents. We show here that Wip1 message is expressed in moderate levels in all organs, but is present at very high levels in the testes, particularly in the postmeiotic round spermatid compartment of the seminiferous tubules. We have confirmed that Wip1 mRNA is induced by ionizing radiation in mouse tissues in a p53-dependent manner. To further determine the normal biological function of… CONTINUE READING

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