Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes.

@article{Chennathukuzhi2003MiceDF,
  title={Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes.},
  author={Vargheese M Chennathukuzhi and Joel M. Stein and Ted Abel and Stacy L Donlon and Shicheng Yang and Juli P. Miller and David M. Allman and Rebecca A. Simmons and Norman B. Hecht},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 18},
  pages={6419-34}
}
Testis-brain RNA-binding protein (TB-RBP), the mouse orthologue of the human protein Translin, is a widely expressed and highly conserved protein with proposed functions in chromosomal translocations, mitotic cell division, and mRNA transport and storage. To better define the biological roles of TB-RBP, we generated mice lacking TB-RBP. Matings between heterozygotes gave rise to viable, apparently normal homozygous mutant mice at a normal Mendelian ratio. The TB-RBP-related and -interacting… CONTINUE READING

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